It shows that the framework itself only uses 60MB and implies any higher usage is due to the application built on top of electron. I'm not sure why uptime matters unless you're assuming there are memory leaks?
The context here is that "the framework" does things 'for' the application it is hosting that the application cannot control, caching various things in memory in a way that makes sense for a browser, but not very much sense for a custom application.
Try this: open a new Chrome instance; look at its memory usage; then load a bunch of tabs (try an Open All on a bookmarks folder), close them all again, and then look at Chrome's memory usage again. It will have increased.
Chrome isn't leaking memory; instead, it is doing the same thing that an Operating System does: weakly reserving memory to optimistically cache stuff, releasing it again if there's enough memory pressure.
This works okay if you only have Chrome itself running. (Even then, its cache fights a bit with the OS page cache. It's certainly no Postgres, intentionally getting the OS page-cache to do its caching for it.) But as soon as you have two separate Chromium instances running (e.g. Chrome itself, plus an Electron app), then each one is going to try to "optimistically" cache as much stuff as it can, until it runs into the memory pressure created by the other instance caching as much stuff as it can, and so each instance will unload just a bit to let the other one cache just a bit more—back and forth—forever. Together, they thrash memory, and it becomes much harder for them to actually accomplish the "weak" part of "weak reservation", instead ending up hoarding all the memory between them.
This is the pretty much the same problem you see if you try to e.g. run two memory-heavy JVM processes (e.g. ElasticSearch) on the same system. Chrome is just one of the few times you'll see this "recapitulation of memory management within the runtime" effect client-side, rather than server-side.
What derefr said about Chrome holding on to memory, and additionally memory leaks are absolutely a concern for related reasons.
(Regarding uptime, it's not at all uncommon for Chrome's memory usage to double or even triple overnight. Partially a function of the websites you have open, sure, but also partially a function of Chrome itself).
