I do, but it's not well supported by a lot of packages. I dig around manually for URLs on unpkg and other JS CDNs, but most libraries' instructions just say "run npm ... or yarn ...". Maybe that complexity's worth it, but understanding what's going on is a barrier for me to use it, just like Julia describes.
I'm very sympathetic to Julia's confusion and your yarn/npm frustration. But consider whether those libraries themselves might also be part of the complexity that are not worth the cost. Julia's trying to use Vue. Vue (and Webpack, and Babel, and the entirety of NPM) nominally exists because it's supposed to improve the developer experience. If instead it contributes negatively in other ways and you have to spend so much time wading through the tangled mess that it confronts you with, what's the point?
Ignoring the nullified value proposition, there are other reasons besides (like security) to reject what the NodeJS/NPM world considers standard practice.
I mainly use big standalone ones that provide enough to be worth it, and far more than I'd build myself. Things like MathJax, JSXGraph, Plotly, and D3 when I properly learn it. Not coincidentally, those aren't too hard to use without NPM.